Contact
45 rue Buffon
CP50
75005 Paris
Responsabilités dans l'unité
Responsable de l’équipe ABI avec Lucie Bittner
Enseignements
Division de Bioinformatique :
- License
- Master
Présentation
Positions
- Head of Atelier de Bioinformatique (UMR ISYEB, MNHN) with Lucie Bittner
- Sorbonne Université (SU) - assistant professor
Interests in Biology
Keywords
- Protein Structure Evolution, Protein Alignment Algorithm, Structural Bioinformatics, Virus, Metaviromics, Computational biology, evolution, bioinformatics.
After a PhD in bioinformatics on protein structural comparison and classification (2001-2005) at Université Pierre and Marie Curie (UPMC, Paris), I have developed skills in viral metagenomics during my post-doctoral fellowship (ATER, 2005-2006) at Université Denis Diderot (Paris). Since I have been recruted at UPMC (2006), and I have divided my time between teaching algorithmic, programming languages and bioinformatics to students in computer science and students in biology, while performing research in various fields of bioinformatics. I have spent 6 months in 2007 in Stanford (California, USA) as invited researcher at Michael Levitt Lab, working on protein structural classification in order to build a database for fold recognition. I have been the principal investigator of a grant for preliminary studies (PEPS BMI 2013 and 2014) for oceanic metaviromics annotation and analyses presented in a conference and resulted in a publication. I have published several major articles on protein structure analyses as well.
Publications
- You can retrieve my scientific publications from Google scholar
- CV
- PhD thesis: Méthodes de d étection des similarités structurales : caractérisation des motifs conservés dans les familles de structures pour lâannotation des génomes
Supplementary Materials of some articles
- Protein Multiple Alignments: Sequence-based vs Structure-based Programs.
The Supplementary materials are here - Analyses of displacements resulting from a point mutation in proteins>
The Supplementary materials are here - Actual courses
- Programmation et structures de données en C ( 2i001)
- Algorithmique appliquée et structures de données ( 2i006)
- Modélisation, algorithmique et programmation pour la biologie ( 3V687)
- Introduction à la biologie et aux algorithmes sur les arbres et les graphes en bioinformatique (AAGB, 4I700)
- Python ( ISUP)
Where and when
- 2016-now : Assistant professor, ISYEB UMR 7205, Sorbonne University, Museum dâHistoire Naturelle (Paris, France)..
- 2010-16 Assistant professor, IMPMC UMR 7590, University Pierre and Marie Curie (Paris, France).
- 2007 Invited scholar at M. Levitt Team (CBS, Stanford, CA)
- 2006-2010: Assistant professor, Analytical Genomics laboratory, University Paris 6 (UPMC).
- 2005-2006: postdoc laboratory Modeling in integrated Biology, University D. Diderot (Paris 7).
- 2002-2005: PhD with Joël Pothier & Pierre Netter (UPMC ; ABI).
Teaching
I teach algorithms, programming languages and bioinformatics at l’ UFR dâIngénierie
Publications
- avril 2023 — Protein Structure and Evolution, La structure des protéines et son évolution. , ,,
- 2023 — La structure des protéines et son évolution. HDR. , , Habilitation à diriger des recherches tex.hal_id: tel-04076823 tex.hal_version: v1,
- 2023 — Soutenance HDR - Protein Structure and Evolution, La structure des protéines et son évolution. , , phd,
- 2023 — Origins and Functional Significance of Eukaryotic Protein Folds. Journal of Molecular Evolution vol. 91, n° 6, p. 854-864,ISSN0022-2844, 1432-1432
- 2022 — Protein folds as synapomorphies of the tree of life. Evolution; international journal of organic evolution vol. 76, n° 8, p. 1706-1719 tex.earlyaccessdate: JUL 2022 tex.eissn: 1558-5646 tex.unique-id: WOS:000823430400001,ISSN0014-3820
- 2022 — Are protein folds reliable phylogenetic markers?. , , dir. Christophe Dessimoz and Marc Robinson-Rechavi tex.hal_id: hal-03959674 tex.hal_version: v1 tex.howpublished: Mathematical and Computational Evolutionary Biology,
- 2021 — « Impact of a Point Mutation in a Protein Structure » in Systematics and the Exploration of Life.. , , dir. Wiley p. 17-31,ISBN978-1-119-47687-0
- 2020 — Analyses of displacements resulting from a point mutation in proteins. Journal of Structural Biology vol. 211, n° 2, p. 107543,ISSN10478477
- octobre 2019 — Protein multiple alignments: sequence-based versus structure-based programs. Bioinformatics (Oxford, England) vol. 35, n° 20, p. 3970-3980,ISSN1367-4803, 1460-2059
- avril 2019 — Protein Multiple Alignments: Sequence-based vs Structure-based Programs. Motivation: Multiple sequence alignment programs have proved to be very useful and have already been evaluated in the… Bioinformatics (Oxford, England) vol. 35, n° 20, p. 3970-3980,