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MAUREL Marie-Christine

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Professor Université Pierre and Marie Curie and Museum National d’Histoire Naturelle
Institut de Systématique, Evolution, Biodiversité
ISYEB- UMR 7205 - CNRS, MNHN, UPMC, EPHE
Sorbonne Universités
Equipe Biologie intégrative des populations, Evolution moléculaire
57 Rue Cuvier - CP39
F-75005 Paris, France
☏ dir. : +33(0)1 40 79 33 81
☏ sec : +33(0)1 40 79 53 33
☏ lab : +33(0)1 71 21 47 24
mcmaurel@mnhn.fr
marie-christine.maurel@upmc.fr



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Short C.V.


 • Themes : Origins of life

Molecular and Structural Archeobiology - Heredity.



 • Context :

One remaining crucial point in the early life history is to understand how evolution passed from complex prebiotic chemistry to simple biology. Current cellular facts allow us to follow the link from chemical to biochemical metabolites, from the ancient to the modern world. Among the primeval organics we focus on the primordial nitrogenous bases scaffolding the initial darwinian ancestor (IDA). In this context, the “RNA world” hypothesis proposes that early in the evolution of life, RNA was responsible for the storage and transfer of genetic information and for the catalysis of biochemical reactions. The discovery of ribozymes at the beginning of the 80’s radically changed the field of molecular biology by revealing the existence of a new continent, the one of RNA – whose extraordinary biological properties have consistently been underlined since then –that could have been preceded by a more ancient RNA World. Several papers are devoted to these aspects of the RNA world (see The RNA World Cold Spring Harbor Lab edition).

We contribute in this field mainly with the study of small ribozymes under extreme conditions (pressure, temperature) as well as with the discovery of a co-ribozyme selected in vitro (by SELEX), the Adenine-dependent hairpin ribozyme (ADHR). We also studied interactions between RNA and compartments as well as peptide-liposome interactions. Finally the persistance and the adaptability of viroids, that is of subcellular viruses considered as vestiges of ancient life, were shown in our laboratory. Along with the structural studies of ASBVd (Avocado Sunblotch Viroid) we showed the replication of this viroid in a non-photosynthetic eukaryote (yeast) as well as in a prokaryote (filamentous cyanobacterium Nostoc PCC7120) .

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Former results - click here
Catalytic mechanism of the sTRSV - click here
In vitro selection of resistant RNA - click here
Cellularisation processes - click here

 • Field of applications

Therapeutic applications - click here
Aptamers directed toward foetal cell markers - click here
At work : click here
Synthesis, evolution of bricks, fragments and small RNAs : click here

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 • Selection of invited presentations to peer-reviewed internationally establishedconferences and/or internationaladvanced schools. All by M.C. Maurel :

-  Ecouter"La méthode scientifique", France culture - Lundi 14 Novembre 2016. "Combien de fois la vie est-elle apparue sur terre"

- EON Workshop on History and Philosophy of Origins Research at ELSI Tokyo-Japan) on August 24-26, 2016.

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Programme AARP-IRM

- Workshop AARP : Advanced Accelerator & Radiation Physics Moscow 6 to 9 juin 2016


- Meeting CECAM, (Program here) « Atomistic simulations in prebiotic chemistry – a dialog between experiment and theory » University Pierre and Marie Curie, Paris,
June 20, 2016 to June 22, 2016
.

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Ecole Berder - Planning 2016

- Ecole de Berder, (Program here) « Le Vivant Autrement » Université Denis Diderot, Paris, 13-15 Juin 2016.


- Tokyo, University of Pharmacy and Life Science, Hachiojishi.
Looking for life elsewhere/ Origins of life connecting Chemistry with biology" Nov 6th, 2015,Tokyo.
- Tanpopo meeting, « Analysis of RNA in spatial samples » Nov 7th, 2015, Tokyo.
- Hiroshima, Shudo University, August 2014 and October 2015

- The 19th Slovenian Science Festival ; Ljubljana, October 8 – 10, 2013.
- Institut Grand-ducal, Luxembourg ; October, 29, 2013.
- FEBS, St Petersbourg ; 5-11 July, 2013.
- « From ancient to modern RNA world and vice versa : Looking through viroids and ribozymes » III world summit on Evolution, Galapagos, June, 2013.
- « From ancient to modern RNA world and vice versa » UNAM, Mexico, September 2011.
- JSPS fellow at Universities of Osaka, Kobe, Nara (lectures) : Japan, January 2011.
- « Pathways towards habitable planets ».Barcelone 14-18 september 2009
- ChemBiogenesis 2009, Lake Balaton, Hungary 23-27 October, 2009.
- Forum International : Evolution. Conférences Science et Société Montréal, 14-16 Novembre 2008, Canada.
- ChemBiogenesis 2008, COST Action CM 0703 « Systems Chemistry » Maratea, Italy 7-10 October, 2008.
- XV International Conference on the Origin of Life, Florence, 24-29 August 2008.
- 1st workshop Italian Astrobiology Society Cortona, May 2008.
- « X Sao Paulo Research Conference : Origens da Vida ». Brazil 19-21 June 2008.
- XVIIIème rencontre de Blois. Keynote speaker : « Paradoxes and controversies in the origins of life studies ». Blois, 28 mai-2 juin 2006.
- ChemBiogenesis COST European Action. Venice 27-30 Septembre 2005.
- ISSOL Meeting for the study of the Origin of Life « Inside the RNA world : from current to ancient RNA ».Chine, Pékin, 8-13 Juillet 2005.
And other 10 Invited presentations to peer-reviewed, internationally established conferences and/or13 international advanced schools in the last 10 years.

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 • Organisation of international conferences

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Cerisy 2016


1- Colloque de Cerisy (17-24 Septembre 2016)
" Life Sciences, Information Sciences "

Organisators : Jean-Charles Pomerol, Dominique Lacroix, Thierry Gaudin, Marie-Christine Maurel.

2- Co-organisation of the international Symposium on RNA ( Paris, Jussieu, France

Something about RNA », 27 Mai 2004 ; « Inside the RNA World », 27 Mai 2005 ; « RNA Tricks »,12 Mai 2006 ; « What’s new about RNA ? », 11 Mai 2007. « Insights in the RNA world ? », 11 Avril 2008 ; « Latest news about RNA », 27 février 2009 ; « Looking through the RNA world », 26 February 2010 ; « Progress in RNA world, Marc, 4, 2011 ; The future of RNA worlds, february, 24, 2012 ; « RNAs never stop »,March,1, 2013.« RNAs in the limelight », February, 28, 2014 ; « What’s New in RNAs »,December,4th, 2015 ;

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RNA Dec.2d, 2016


« RNAs more an more », December, 2d, 2016.


3- Co-organisation of Lectures on concepts in Biology - M-C.Maurel et A-L Haenni .

Institut Jacques-Monod (6 conférences/an) « Hypothèses, Théories Concepts en Biologie ».
Institut Jacques-Monod. (2005-2009) - M-C. Maurel, J-L. Baumont, Colloque « Les lundis de la connaissance », Nice, juin 2009 - M-C. Maurel et M. Gérin, Colloque ENS : Auto-organisation
et/ou evolution biologique, 3 octobre 2008.

4- Co-organisation Muséum d’Histoire Naturelle-Marseille Colloquium, M-C. Maurel et B. Brun. - Nouveauté et évolution : apparition du nouveau dans l’histoire du vivant, 28 Juin 2001 - L’inné et l’acquis dans l’évolution, 18 June 2002.

Co-organisation de Conférences au Centre d’Etudes du Vivant : - Co-organisation M-C. Maurel et P-A Miquel (students could obtain credit for the philosophy DEA from Université Paris I)
De la notion de programme génétique au problème des origines du programme ”. Evelyn Fox-Keller, Henri Atlan, Michel Morange, Miroslav Radman, Paul-Antoine Miquel, Marie-Christine Maurel, etc. (2000-2002 : 6 seminars/yr) ) « Réductionnisme et émergence »). Jean-Claude Dupont, Jean-Jacques Kupiec , Jacques Ricard, Sandra Laugier, Christian de Duve. (2002-2004 : 6 seminars/yr)
Conférences de Graham Cairns-Smith, Elizabeth de Fontenay, Jean-Marc Levy-Leblond, Bernard Andrieu, etc.

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• Recents publications


2017



PDF

- MC Maurel,(2017) Exoplanètes, quelle vie menez-vous ? L’illustré, 10-17.
http://www.illustre.ch/magazine/exo...

- Zaccai, G., Maurel, M.C., Yonath, A."The fluctuating RNA ». ISTE. In press.


PDF
- Maurel M.C. (2017) Les origines de la vie, Poche-Le pommier.https://www.comme-un-roman.com/livr...



PNG - 697.4 ko

- Maurel M.C. (2017) “Ne réduisons pas la vie à ce que nous en connaissons”., In Le mystère des origines, Sciences et Avenir Hors-série. Février 2017.



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- Misuraca L., Natali F., da Silva L., Peters J., Demé B., Ollivier J., Seydel T., Laux-Lesourd V., Haertlein M., Zaccai G., Deamer D., Maurel M.C. (2017) Mobility of a Mononucleotide within a Lipid Matrix : A Neutron Scattering Study. Life, 7, 2. Available at : http://www.mdpi.com/2075-1729/7/1/2 [Accessed January 18, 2017].

2016

- Zaccai G., Natali F., Peters J., Řihová M., Zimmerman E., Ollivier J., Combet J., Maurel M.C., Bashan A., Yonath A. (2016) The fluctuating ribosome : thermal molecular dynamics characterized by neutron scattering. Scientific Reports, 6, 37138. Available at : http://www.nature.com/articles/srep37138 (Link to pdf)

- Maurel M.-C., Leclerc F. (2016) From Foundation Stones to Life : Concepts and Results. Elements, 12, 407–412. Available at : http://elements.geoscienceworld.org/lookup/doi/10.2113/gselements.12.6.407 [Accessed January 18, 2017].

- Akouche M., Jaber M., Zins E.-L., Maurel M.C., Lambert J.-F., Georgelin T. (2016) Thermal Behavior of “font-variant:small-caps ;” -Ribose Adsorbed on Silica : Effect of Inorganic Salt Coadsorption and Significance for Prebiotic Chemistry. Chemistry - A European Journal, 22, 15834–15846. Available at : http://onlinelibrary.wiley.com/doi/... (Link to pdf)

PDF - 2 Mo

- Leclerc, F. , Zaccai, G., Vergne, J., Řìhovà, M., Martel, A. & Maurel, M.C. Self-assembly Controls Self-cleavage of HHR from ASBVd (−) : a Combined SANS and Modeling Study. Sci. Rep. 6, 30287 http://www.nature.com/articles/srep30287 (2016).

PDF - 1.3 Mo

- Latifi, A., Ch. Bernard, L. Da Silva, Y. Andéol, Amine Elleuch, V. Risoul, J. Vergne, and M. C. Maurel, ’Replication of Avocado Sunblotch Viroid in the Cyanobacterium Nostoc Sp. PCC 7120’, Journal of Plant Pathology & Microbiology, 07 (2016) http://dx.doi.org/10.4172/2157-7471.1000341


2015
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- Maurel, M. C., and P. Grandcolas, Origins – Studies in Biological and Cultural Evolution. Workshops ‘Origins’ Institut de Systématique, Evolution, Biodiversité (ISYEB - UMR 7205 CNRS MNHN UPMC EPHE, Sorbonne Universités) Paris, France, October 24, 2014 ; BIO Web of Conferences, volume 4, EDP Sciences, www.bio-conferences.org/, 2015

- Maurel, M. C., and P. Grandcolas, ‘The Quest for the Origins in Evolutionary Biology’, in Origins – Studies in Biological and Cultural Evolution. Workshops ‘Origins’ Institut de Systématique, Evolution, Biodiversité (ISYEB - UMR 7205 CNRS MNHN UPMC EPHE, Sorbonne Universités) Paris, France, October 24, 2014., ed. by M. C. Maurel and P. Grandcolas ; Paris : BIO Web of Conferences, volume 4, EDP Sciences, www.bio-conferences.org, 2015, pp. 0001 – p 1–5

- Kawamura, K., Da Silva,L., Ogawa,M., Konagaya, N. and Maurel, M.C. ‘Verification of Chemical Evolution of RNA under Hydrothermal Environments on the Primitive Earth’, ed. by M.-C. Maurel and P. Grandcolas, BIO Web of Conferences, 4 (2015), 00011 <http://dx.doi.org/10.1051/bioconf/2...>

- Maurel, Marie-Christine, ‘From neonts to filionts and Their Progenies... : Biodiversity Draws Its Origins from the Origins of Life Itself’, ed. by M.-C. Maurel and P. Grandcolas, BIO Web of Conferences, 4 (2015), 00014 <http://dx.doi.org/10.1051/bioconf/2...>

- Maurel, Marie-Christine., ’Origine et Développement de La Vie Sur Terre’  : "rôle de L’eau". pp 24-25. In L’eau à découvert, CNRS Editions Paris, (2015)

- Da Silva, L., Maurel, M-C., Deamer, D. Salt-Promoted Synthesis of RNA-like Molecules in Simulated Hydrothermal Conditions. 2015 J. Mol Evol. 80:86–97

- Maurel, M-C. Des étoiles à la vie. Rôle de la photochimie dans les origines et le développement de la vie. L’Actualité chimique - juin-juillet 2015 - n° 397-398

- Georgelin, T., Akouche, M., Fournier, F., Zins, E.-L., Jaber, M., Maurel, M.-C., Lambert. J.-F. Stabilisation of Ribofuranose by a mineral surface. Carbohydrate Research, 402 (2015) 241–244

- Maurel, M-C. Quels sont les éléments indispensables à la vie ? Textbook Biochimie. N. Latruffe. Dunod, Ed. 2015

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- Vergne, J. Cottin, H., Da Silva, L., Brack, A., Chaput, D., Maurel, M.-C. The AMINO experiment : RNA stability under solar radiation studied on the EXPOSER facility of the International Space Station. International Journal of Astrobiology, 2015, 14:99-103

- Cottin et al. The AMINO experiment : a laboratory for astrochemistry and astrobiology on the EXPOSE-R facility of the International Space Satation, International Journal of Astrobiology, 2015, 14:67-77

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 • Previous publications 2015 Click here




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